منابع مشابه
Sodium-coupled neurotransmitter transport: structure, function and regulation.
The removal of neurotransmitters by their transporters--located in the plasma membranes of nerve terminals and glial cells--plays an important role in the termination of synaptic transmission. In the last 3 years, many neurotransmitter transporters have been cloned. Structurally and functionally they can be divided into two groups: glutamate transporters, of which to date three have been cloned...
متن کاملNeurotransmitter-stimulated ion transport by cultured porcine vas deferens epithelium.
A collagenase-based dissociation technique has been developed to routinely establish monolayer cultures of freshly isolated porcine vas deferens epithelium. Cells isolated from each tissue are transferred to 25-cm(2) tissue culture flasks and grown in a standard cell culture medium. Flasks reach confluency in 3-4 days, and cells are subsequently seeded onto permeable supports. Cultured cells di...
متن کاملInteraction of intracellular ion buffering with transmembrane-coupled ion transport
The role of the Na/Ca exchanger in the control of cellular excitability and tension development is a subject of current interest in cardiac physiology. It has been suggested that this coupled transporter is responsible for rapid changes in intracellular calcium activity during single beats, generation of plateau currents, which control action potential duration, and control of intracellular sod...
متن کاملSodium-coupled neurotransmitter transporters.
Sodium-coupled neurotransmitter transporters are located in the plasma membranes of neurons and glia, where they are present at high density in those areas of the cell membrane that face the synapse (Figure 1). They serve to keep the extracellular neurotransmitter concentrations sufficiently low, so that the postsynaptic receptors are able to detect signaling by the presynaptic nerve cell in th...
متن کاملMetamorphosis of research on ion-coupled metabolite transport.
A defining moment in the history of active transport research came in August 1960, in a symposium at the Czeckoslovak Academy of Sciences, which became known among membrane biologists as the Prague Symposium (Kleinzeller and Kotyk, 1961). By that date, the enzymatic nature of sodium transport in animal cells had been demonstrated (Skou, 1957) and a generalized concept of transport-related, vect...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 1989
ISSN: 0955-0674
DOI: 10.1016/0955-0674(89)90042-2